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. 2021 Mar 25;25(10):4623–4636. doi: 10.1111/jcmm.16312

FIGURE 5.

FIGURE 5

AAV‐2 mediated overexpression of GDF11 in vascular SMCs prevented synthetic phenotype and proteolytic activity. Western blotting (A, B), RT‐qPCR (C) were used to determine the expression of GDF11 in SMCs after AAV‐2 infection. Representative western blotting of p‐Smad‐2/3 (D) and their quantification (E) in AAV‐2 infected SMCs. RT‐qPCR was performed to examine the phenotypic markers (F) and MMPs (G) in GDF11 overexpressing SMCs with or without SB‐431542 treatment. Data are presented as mean ± SD (n = 3). **P < .01 vs AAV2‐EV group, ## P < .01 vs AAV2‐GDF11 group