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Smad3 deficiency inactivates cardiac NF‐kB signalling and suppresses myocardial miR‐21 while up‐regulating miR‐29b in db/db mice. A, Western blot analysis of p‐IκBα and p‐p65. B, C, Real‐time PCR analysis of miR‐21 and miR‐29b. Values are expressed as mean ± SE for group of eight mice. *P 05 and **P 01 compared with Smad3(S3) WT‐db/m group; # P 05, ## P 01 and ### P 001 compared with Smad3 (S3) WT‐db/db and Smad3+/−db/db groups
