Figure 4 –

YAP1 and TAZ fusions in different cancer types. A: Overview of known YAP1 and TAZ gene fusions and the cancer types they are found in. B: Structural features that are shared between known YAP1 fusion proteins. All known YAP1 fusions retain the YAP1 TID domain necessary for binding to TEADs and lose the S397 residue of wild type YAP1 important for Hippo-mediated proteasomal degradation. In addition, the C-terminal fusion partner contains a nuclear localization sequence that mediates the nuclear localization of the YAP1 fusion proteins. The C-terminal fusion partner also contains a transactivation domain (TAD) that surrogates for the YAP1 TAD that is lost in the YAP1 fusions. C) Hallmarks of known YAP1 fusions. Figure was created with BioRender.com