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Oncogenic mechanisms of YAP1 fusions. Left: Regulation of wild type YAP1 activity by the Hippo pathway. Right: YAP1 fusion proteins are resistant to Hippo pathway-mediated regulation, due to both constitutive nuclear localization (mediated by the nuclear localization sequence present in the C-terminal fusion partner sequence) and resistance to proteasomal degradation (mediated by the loss of YAP1 S397 in the fusion protein). Figure was created with BioRender.com
