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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Adv Drug Deliv Rev. 2021 Jan 12;172:275–295. doi: 10.1016/j.addr.2021.01.006

Figure 8:

Figure 8:

(A) Example of thermoresponsive ABA block copolymer gelators which feature two hydrophilic PEG blocks flanking a midblock prepared from a polymer which transitions to hydrophobic according to a temperature stimulus. Shown are the structures of PEG-PPO-PEG and PEG-PLLA-PEG copolymers. These polymers transition from a soluble sol state to a hydrogel state characterized by packed micelle structures. (B) Example of thermoresponsive BAB block copolymer gelators which feature a PEG midblock flanked by two blocks prepared from a polymer which transitions to hydrophobic according to a temperature stimulus. Shown are the structures of PLGA-PEG-PLGA and PCL-PEG-PCL copolymers. These copolymers transition from a soluble sol state to a hydrogel state characterized by self-associating aggregates of the ‘A’ blocks which are bridged by soluble PEG chains.