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. 2021 Apr 15;38(5):2613–2630. doi: 10.1007/s12325-021-01656-3

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© Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 3 — Tornado diagram showing the variation in ICER value based upon one-way deterministic parameters changes and scenarios. a Pembrolizumab monotherapy versus Cetuximab + Platinum + 5-FU in patient with CPS ≥ 1 and b Pembrolizumab combination therapy versus Cetuximab + Platinum + 5-FU in the total population. CPS combined positive score, GG generalized gamma, mg milligram, m meter, OS overall survival, Pembro pembrolizumab, PFS progression-free survival, QALY quality-adjusted life-year, 1L first line, 5-FU 5-fluorouracil. AR $74 = 1 USD = 0.84 euro