Table 2.
Treatment intensity and adherence, by year of follow-up
| Index year | Year 1 | Year 2 | Year 3 | Year 4 | |
|---|---|---|---|---|---|
| n | 14,944 | 14,338 | 11,716 | 6890 | 2558 |
| On LLT (%) | 14,944 (100%) | 12,956 (90.4%) | 10,019 (85.5%) | 5695 (82.7%) | 2029 (79.3%) |
| High-intensitya (%) | 1391 (9.3%) | 1448 (11.2%) | 1260 (12.6%) | 695 (12.2%) | 267 (13.2%) |
| Moderate-intensity (%) | 12,787 (85.6%) | 10,830 (83.6%) | 8214 (82.0%) | 4688 (82.3%) | 1659 (81.8%) |
| Low-intensity (%) | 766 (5.1%) | 678 (5.2%) | 545 (5.4%) | 312 (5.5%) | 103 (5.1%) |
| Not on LLT (%) | – | 1382 (9.6%) | 1697 (14.5%) | 1195 (17.3%) | 529 (20.7%) |
| Adherent to LLTb (%) | 9989 (66.8%) | 7989 (61.7%) | 6333 (63.2%) | 3637 (63.9%) | 1410 (69.5%) |
aProportions of patients on high-, moderate- and low-intensity LLT are calculated out of the number of patients who were on LLT
bAdherence defined as proportion of days covered ≥ 0.8; proportions are calculated out of those on LLT during each year