Table 2.
Urinary excretion rates of DMA, ADMA, SDMA and their composites, their ratios in the healthy kidney donors before and after donation and in the renal transplant recipients (RTR) and their percentage differences
| Urinary excretion rate (µmol/24 h) or ratio | Pre-donation (n = 121) | Post-donation (n = 97) | RTR (n = 691) | Difference RTR-pre (%) |
Difference RTR-post (%) |
P valuea | |
|---|---|---|---|---|---|---|---|
| A | B | C | C–A | C–B | A vs. C | B vs. C | |
| DMA | 426 [360–480] | 411 [327–515] | 429 [353–516] | 0.7 | 4.2 | 0.41 | 0.19 |
| ADMA | 60 [49–70] | 36 [31–46] | 30 [22–40] | − 49.3 | − 15.1 | < 0.001 | < 0.001 |
| SDMA | 61 [50–70] | 50 [38–64] | 50 [40–63] | − 18.3 | 0.8 | < 0.001 | 0.88 |
| DMA + ADMA | 490 [419–536] | 440 [361–560] | 460 [381–551] | − 6.1 | + 4.3 | 0.05 | 0.40 |
| DMA + ADMA + SDMA | 550 [482–613] | 498 [402–628] | 513 [425–609] | − 6.7 | + 2.9 | 0.02 | 0.47 |
| (DMA + ADMA)/SDMA | 8.2 [7.1–9.3] | 8.8 [8.0–10.8] | 9.0 [7.8–10.9] | + 9.4 | + 2.3 | < 0.001 | 0.69 |
| SDMA/ADMA | 1.03 [0.90–1.17] | 1.33 [1.08–1.63] | 1.71 [1.35–2.17] | + 39.8 | + 22.2 | < 0.001 | < 0.001 |
Data are presented as median [IQR]. To obtain maximal statistical power for our analyses, we did not only include kidney donors with both pre- and post-donation data available, but also included participants with either pre-donation or post-donation data available. Therefore, the number of kidney donors is 121 pre-donation and 97 post-donation
Bold numbers indicate statistical significance (P value < 0.05)
aStatistical analyses were performed between A and C, and between B and C using the Kruskal–Wallis test