Table 3.

Severe Asthma Biomarkers

Biomarker	Endotype	Scientific Reference
Elevated Eosinophils	T2-hi	(Teach et al. (38), Price et al. (58))
High Total IgE	T2-hi	(Zoratti et al. (30))
Presence of specific IgE or allergy skin prick testing to assess inhalant allergen sensitization	T2-hi	(Zoratti et al. (30))
Elevated Fractional exhaled nitric oxide	T2-hi	(van der Valk et al. (59), van
(FeNO)		Vliet et al. (60), Teach et al. (38))
Elevated Neutrophils	T2-hi/T2-lo	(Teague et al. (27))
Elevated Periostin	T2-hi	(Izuhara et al. (61))