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. 2021 Apr 26;8:609300. doi: 10.3389/fcvm.2021.609300

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Copyright © 2021 Xiao, Reddy, Xue, Liu, Chen, Li, Ling and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rat atrial fibrosis model had elevated expression of miR-205 and decreased expression of P4HA3. The blood pressure of rats was measured (A) (n = 6). The pathology of rat atrial tissues was observed by H&E staining (B) (n = 6), and the collagen fiber deposition of rats was detected by Masson staining (C) (n = 6). qRT-PCR was utilized to inspect the mRNA level of miR-205 (D) (n = 6). The mRNA and protein levels of collagen I, α-SMA, and P4HA3 were analyzed by qRT-PCR (E) and Western blot (F) (n = 6); *P < 0.05, **P < 0.01.