Table 2.
List of the genes included in the study.
| Gene | Chr | Start | End | OMIM entry | Phenotype (OMIM) | Reference |
|---|---|---|---|---|---|---|
| ABO | chr9 | 133255602 | 133275214 | 110300 | Blood group, ABO system | (24) |
| ACKR1 | chr1 | 159203307 | 159206498 | 613665 | Blood group, Duffy system | (24) |
| ADORA2B | chr17 | 15944917 | 15975746 | 612446 | (24) | |
| ATP2B4 | chr1 | 203626561 | 203744081 | 613665 | Protection against malaria vivax | (24) |
| C6 | chr5 | 41142234 | 41261438 | 217050 | (24) | |
| CD36 | chr7 | 80369575 | 80674409 | 173510 | Susceptibility to/reduced risk of cerebral malaria | (24) |
| CD40LG | chrX | 136648193 | 136660390 | 308230 | (24, 25) | |
| CISH | chr3 | 50606522 | 50611831 | 602441 | Susceptibility to malaria | |
| CR1 | chr1 | 207496268 | 207639409 | 120620 | Resistance to severe malaria | (24, 25) |
| FCGR2A | chr1 | 161505430 | 161518558 | 146790 | Susceptibility to severe malaria | |
| FCGR2B | chr1 | 161663161 | 161678654 | 604590 | Resistance to malaria | |
| FUT9 | chr6 | 96015974 | 96215612 | 606865 | Susceptibility to placental malarial infection | |
| G6PD | chrX | 154532000 | 154547572 | 305900 | Resistance to malaria due to G6PD deficiency | (24) |
| GNAS | chr20 | 58841622 | 58909188 | (24) | ||
| GYPA | chr4 | 144109304 | 144140751 | 617922 | Resistance to malaria | |
| GYPB | chr4 | 143996106 | 144019339 | 617923 | Resistance to malaria | |
| GYPC | chr2 | 126656158 | 126696667 | 110750 | Resistance to malaria | |
| HBB | chr11 | 5225464 | 5227197 | 141900 | Resistance to malaria | (24) |
| HMOX1 | chr22 | 35381096 | 35394207 | (25) | ||
| ICAM1 | chr19 | 10271120 | 10286615 | 147840 | Susceptibility to cerebral malaria | (24) |
| IFNa17 | chr9 | 21227243 | 21228222 | (25) | ||
| IFNAR1 | chr21 | 33324970 | 33359864 | (25) | ||
| IFNb1 | chr9 | 21077104 | 21077942 | (25) | ||
| IFNG | chr12 | 68154768 | 68159740 | (25) | ||
| IL10 | chr1 | 206767602 | 206772494 | (24) | ||
| IL13 | chr5 | 132658173 | 132661110 | (24) | ||
| IL1A | chr2 | 112773915 | 112784590 | (24) | ||
| IL1B | chr2 | 112829751 | 112836779 | (24) | ||
| IL22 | chr12 | 68248242 | 68253604 | (24) | ||
| IL4 | chr5 | 132673989 | 132682678 | (24, 25) | ||
| IRF1 | chr5 | 132481609 | 132490773 | (24, 25) | ||
| LTA | chr6 | 31572054 | 31574324 | (24) | ||
| NCR3 | chr6 | 31588895 | 31593006 | 611550 | Susceptibility to mild malaria | |
| NOS2A | chr17 | 27756766 | 27800529 | 163730 | Resistance to malaria | (25) |
| PECAM1 | chr17 | 64319415 | 64390860 | (25) | ||
| RNASE3 | chr14 | 20891399 | 20892348 | (25) | ||
| SLC4A1 | chr17 | 44248390 | 44268135 | 109270 | Resistance to malaria | |
| SPTB | chr14 | 64746283 | 64879907 | (24) | ||
| TGFB2 | chr1 | 218345284 | 218444619 | (25) | ||
| TIRAP | chr11 | 126283087 | 126294933 | 606252 | Protection against malaria | |
| TLR1 | chr4 | 38796255 | 38804791 | (24, 25) | ||
| TLR4 | chr9 | 117704403 | 117724735 | (24, 25) | ||
| TLR5 | chr1 | 223109404 | 223143248 | (25) | ||
| TLR6 | chr4 | 38823715 | 38856817 | (24) | ||
| TLR9 | chr3 | 52221080 | 52226163 | (24, 25) | ||
| TNF | chr6 | 31575565 | 31578336 | 191160 | Susceptibility to cerebral malaria | (24, 25) |
| ACE2 | chrX | 15561033 | 15602069 |
Genes are reported with gene symbol, chromosome, start and end genomic position (hg38 coordinates). The MIM number is reported for all the genes associated with malaria in OMIM, and the corresponding phenotype if present. Two other publications were investigated to complete the list, as reported in the last column (“Reference”).