Table 5.

List of variants finally selected.

	rs ID	Consequence	Gene symbol (input)	Spearman ρ	Spearman FDR	Captured alleles (Tagger)	eQTL genes associated	eQTLs slope lung	eQTL slope whole blood
Positive correlation	rs72717040	Intronic	FCGR2A	0.48806	0.00431	rs17400517	FCGR2C, HSPA7	–	–
	rs17622656	Intronic	IRF1	0.51287	0.00208		SLC22A5	–	–
	rs8081547	Intronic	ADORA2B	0.55595	0.00049		CENPV	–	–
	rs7683365	Missense	GYPB	0.58510	0.00016	rs7662277, rs7666297, rs7666296, rs12499907, rs12499906, rs10002395, rs10025455, rs7661933	GYPE	–	–
Negative correlation	rs8176725	Intronic	ABO	−0.45895	0.00914		ABO	+	+
	rs6840234	Intronic	GYPB	−0.55690	0.00047	rs6857129, rs4835127, rs1473055, rs6537238, rs4835126, rs6816184	GYPE, FREM3	–	–
	rs4646120	Intronic	ACE2	−0.47397	0.00638		PIR	+	+
	rs1978124	Intronic	ACE2	−0.53219	0.00109		PIR	+	+

The list of SNVs positively and negatively correlated with COVID-19 is reported in the upper and lower part of the table, respectively. These variants are strongly associated to COVID-19 (FDR < 0.01), are associated to eQTL in at least four tissues, including lung, and are driver-variants of other alleles. The first three columns represent the rsID, the consequence of the SNV on the gene, and the name of the malaria-associated gene where the variant is located. Spearman ρ and FDR are reported for each tag SNP. All the variants captured by the tag SNP are listed in “Captured alleles (Tagger)” column. The last three columns indicate the eQTL genes associated and the slope of the eQTL for lung and whole blood (+, positive; –, negative).