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The formation of IS mediated by CAR and bsAb. (A) The structure of CAR-IS. The microclusters of CAR are dispersed in a multipolar manner surrounded by disorganized LFA-1 without a clear boundary of pSMAC. (B) The structure of bsAb-IS. Similar to TCR-IS, BsAb-IS has a conventional mature IS structure, with organized cSMAC, and a LAF-1 ring and actin accumulation at the periphery.
