Table 3. Comparison of radiological characteristics for eHCC†‡.
| Imaging method | No. of lesions (eHCC/adHCC) | Indicators | Cutoff values | Sensitivity (%) | Specificity (%) | Accuracy (%) | AUC |
|---|---|---|---|---|---|---|---|
| EOB-MRI | 71/92 | All lesions | Pre-contrast ratio (≥0.981) | 0.592 | 0.880 | 0.755 | 0.736 |
| Post-contrast ratio (≥0.610) | 0.915 | 0.522 | 0.693 | 0.719 | |||
| Pre (≥0.981) + post (≥0.610) | 0.535 | 0.891 | 0.736 | 0.706 | |||
| 27/73 | Hypervascular lesions | Pre-contrast ratio (≥0.984) | 0.593 | 0.849 | 0.780 | 0.721 | |
| Post-contrast ratio (≥0.625) | 0.926 | 0.548 | 0.650 | 0.737 | |||
| Pre (≥0.984) + post (≥0.625) | 0.593 | 0.863 | 0.790 | 0.728 | |||
| 44/19 | Non-hypervascular lesions | Pre-contrast ratio (≥0.907) | 0.773 | 0.947 | 0.825 | 0.860 | |
| Post-contrast ratio (≥0.609) | 0.841 | 0.579 | 0.762 | 0.710 | |||
| Pre (≥0.907) + post (≥0.609) | 0.659 | 1.000 | 0.762 | 0.830 | |||
| SCEUS | 71/92 | All lesions | PP (iso) | 0.915 | 0.402 | 0.626 | 0.659 |
| PVP (iso) | 0.859 | 0.924 | 0.896 | 0.892 | |||
| PP (iso) + PVP (iso) | 0.846 | 0.920 | 0.888 | 0.883 | |||
| EOB-MRI+SCEUS | 71/92 | All lesions | Post-contrast ratio (≥0.610) + PVP (iso) | 0.789 | 0.924 | 0.865 | 0.856 |
†, this diagnosis is made by differential eHCC from advanced HCC. Advanced HCC was defined as taking well, moderately, poorly diff. HCC as a whole. ‡, HCC, hepatocellular carcinoma; eHCC, early HCC; SCEUS, Sonazoid contrast enhanced ultrasound; EOB-MRI, gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid magnetic resonance imaging; AP, arterial phase, PP, portal phase; PVP, post-vascular phase; AUC, area under the curve.