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. 2021 Apr 26;8:643358. doi: 10.3389/fcvm.2021.643358

Figure 2.

Figure 2

All-cause death, cardiovascular death, and hospitalization for heart failure in HFpEF patients according eGFR. In model 1, the following parameters were adjusted: age, sex, race. In model 2, the following parameters were adjusted: age, sex, race, MI, previous hospitalization for heart failure, smoking status, alcohol intake, EF, HR, diuretics. In model 3, the following parameters were adjusted: the parameters of model 2 along with stroke, DM, HB, hypertension, atrial fibrillation, ICD, COPD, NYHA class, implanted pacemaker, dyslipidemia, beta blockers, ACE-I/ARB, CCB and randomization arm (spironolactone or placebo). CI, confidence interval; HFpEF, heart failure with preserved left ventricular ejection fraction; HR, hazard ratio; MI, myocardial infarction; EF, ejection fraction; HR, heart rate; DM, diabetes mellitus; HB, hemoglobin; ICD, implanted cardioverter-defibrillator; COPD, chronic obstructive pulmonary disease; NYHA, New York Heart Association; ACEI, angiotensin-converting enzyme inhibitors; ARB, angiotensin II receptor blockers; CCB, calcium-channel blockers.