TABLE 1.

Prioritized associated genes in Gene4PD.

High confidence genes (score ≥ 20) (N = 25)	Strong associated genes (score of 10–20) (N = 19)	Suggestive associated genes (score of 5–10) (N = 66)
PRKN#, PINK1#, LRRK2#, SNCA#, GBA#, PARK7#, GCH1, PLA2G6#, ATP13A2#, VPS35#, DNAJC13#, FBXO7#, POLG#, TMEM230#, SYNJ1#, GIGYF2#, VPS13C#, LRP10#, RAB39B, CHCHD2, MAPT, TH, EIF4G1#, ASNA1, and DNAJC6#	TNR, PODXL, CSMD1, HTRA2#, GPRIN3, PPM1K, TARDBP, SLC6A3, ATP10B, PTEN, MMRN1, VAPB, L2HGDH, SPP1, SCN3A, NAP1L5, ITPR1, PZP, UQCRC1, DCTN1, ABCG2, ATOH1, CCSER1, FAM13A, FAM13A-AS1, GRID2, HERC3, HERC5, HERC6, PIGY, PKD2, PYURF, SMARCAD1, TIGD2, ANKRD30A, DIS3, MNS1, and PTRHD1	RIC3, SLC18A2, COL6A5, ATP1A3, CD36, CP, GRN, PSEN1, SMPD1, FAM83A, KIF21A, PTPRH, COMT, SPG7, MCCC1, PLIN4, TNK2, UCHL1#, APOE, OGN, WDR45, TBC1D24, TWNK, BST1, CAPS2, CEL, SVOPL, ATG4C, CABIN1, COL15A1, DARS, DNAH8, ELOA2, FAM71A, FAM90A1, FER1L6, GH2, GPATCH2L, GRAMD1C, IFI35, KALRN, KCNK16, LIPI, LPA, MAP3K6, MS4A5, NUS1, OR8B3, PCDHA9, PRB3, PRMT3, PRSS48, PTCHD3, RFPL2, SCARF2, SPPL2C, TMEM134, UHRF1BP1L, USP20, ZNF516, and ZNF543

^#Known PD-causing genes [Blauwendraat et al. (2019b). The genetic architecture of Parkinson’s disease. Lancet Neurol].124 PD-associated genes (score ≥ 5) were classified into three grades, including high confidence (score ≥ 20), strong associated (score of 10–20), and suggestive associated (score of 5–10).