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. 2021 Apr 26;12:649112. doi: 10.3389/fimmu.2021.649112

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Copyright © 2021 Zhang, van Oostrom, Li and Savelkoul

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BAFF and APRIL bind to BAFF receptor (BAFFR) and B−cell maturation antigen (BCMA), respectively. BAFF also binds to BCMA. Both BAFF and APRIL bind to TACI receptor. Engagement of BAFFR by BAFF delivers survival signals and class switch recombination (CSR) to peripheral B cells, while engagement of BCMA by BAFF or APRIL delivers survival signals to plasma cells, but has no effect on CSR. BAFF-R stimulation sequesters TRAF, which activates the formation and nuclear accumulation of RelB:p52 complex driving the survival of the B-cells.