Table 2.
Technical aspects of the included studies.
| References | Radiotracer | Hybrid imaging modality | Fasting before radiotracer injection | Mean/median radiotracer injected activity | Time between radiotracer injection and image acquisition | Image analysis | Other imaging performed for comparison |
|---|---|---|---|---|---|---|---|
| Markowski et al. (31) | 18F-DCFPyL | NA | NA | 333 MBq | 60 min | Visual | NA |
| Hong et al. (32) | 18F-DCFPyL | PET/CT with low-dose CT | NA | 338.8 ± 25.3 (270.1–370) MBq |
74.4 ± 10.4 min | Visual | CT, mpMRI, bone scan, 18F-NaF PET/CT, and 18F-fluciclovine PET/CT |
| Wei et al. (33) | 18F-DCFPyL | PET/CT with low-dose CT | NA | Mean: 333 MBq (299.7–366.3) MBq |
60 ± 10 min | Visual | CT, mpMRI, and bone scan |
| Jansen et al. (34) | 18F-DCFPyL | PET/CT with low-dose CT | NA | Median: 314.4 MBq (257.7–328.6) MBq |
120 ± 21 min | Visual | NA |
| Rowe et al. (35) | 18F-DCFPyL | NA | NA | No more than 333 MBq | 60 min | Visual and semiquantitative (SUVmax) | NA |
| Mena et al. (36) | 18F-DCFPyL | PET/CT with low-dose CT | NA | Mean: 299.3 MBq (229.4–325.6) MBq |
120 min | Visual and semiquantitative (SUVmax, TV, VOI) | NA |
| Rousseau et al. (37) | 18F-DCFPyL | PET/CT with low-dose CT | Yes (at least 4 h) | 369.2 ± 47.2 (237–47 ×4) MBq |
120 min | Visual and semiquantitative (SUVmax, SUVpeak, SUL, TLG, SUVratio) | NA |
| Wondergem et al. (38) | 18F-DCFPyL | PET/CT with low-dose CT or contrast-enhanced CT | NA | Median: 311 MBq (284–325) MBq |
120 min | Visual | NA |
| Dietlein et al. (39) | 18F-DCFPyL | PET/CT with low-dose CT | Yes (at least 4 h) | 269.8 ± 81.8 MBq | 120 min | Visual and semiquantitative (SUVmax) | 68Ga-PSMA-11 PET/CT |
NA, not available; PET/CT, positron emission tomography/computed tomography; mpMRI, multiparametric magnetic resonance imaging; 18F-DCFPyL, 2-(3-{1-carboxy-5-[(6-[18F] fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid; MBq, megabecquerel.