Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 26;12:594376. doi: 10.3389/fimmu.2021.594376

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Grassi, Vanini, De Santis, Romagnoli, Aiello, Casetti, Cimini, Bordoni, Notari, Cuzzi, Mosti, Gualano, Palmieri, Fraziano, Goletti, Agrati and Sacchi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

PMN-MDSC discriminate active TB and LTBI. (A) Gating strategy used to identify MDSC: in the morphological gate (FSC/SSC) we excluded debris, then we gated Lin-/HLA DRlow/- cells. In this gate, we selected CD11b+CD33+ cells (MDSC). Then, the expression of CD14, CD15 is shown. The percentage of Lin-/HLA-DR-/CD11b+/CD33+ has been calculated in the morphological gate. (B) PMN-MDSC frequency in active TB (18), LTBI (19) and HD (12). Results are shown as Box and Whiskers. The Kruskall-Wallis test (with Dunn’s multiple comparison posttest) was applied. (C) Receiver operating characteristic (ROC) curve for the PMN-MDSC frequency. Right panel TB vs HD, left panel TB vs LTBI. (D) Receiver operating characteristic (ROC) curve for the Mo/Ly ratio. Right panel TB vs HD, left panel TB vs LTBI. PMN-MDSC: polymorphonuclear-myeloid-derived suppressor cells; TB, tuberculosis; LTBI, latent tuberculosis infection; HD, healthy donors.