Table 3.
Comparisons of All the Variables Between Baseline and 1-Year Follow-Up in Patients With Multiple Sclerosis
| Variables | Baseline (N = 44) | 1-y Follow-Up (N = 44) | P Values | |
|---|---|---|---|---|
| Vision function by LCLA test | 2.5% LCLA | 51.0 ± 8.7 | 51.6 ± 9.5 | 0.606 |
| 1.25% LCLA | 26.4 ± 10.3 | 26.5 ± 10.3 | 0.967 | |
| BCVA | LogMAR | 0.0 ± 0.2 | 0.0 ± 0.2 | NA |
| RGC function by PERG test | Amplitude (nV) | 962.8 ± 381.9 | 969.1 ± 361.4 | 0.952 |
| Latency (ms) | 50.8 ± 3.4 | 51.1 ± 3.7 | 0.818 | |
| pRNFL birefringence by PS-OCTa | Average PR/UD (degree/100 µm) | 4.3 ± 2.5 | 3.7 ± 3.0 | 0.342 |
| Temporal PR/UD (degree/100 µm) | 5.0 ± 3.9 | 3.0 ± 2.9 | 0.010 | |
| Superior PR/UD (degree/100 µm) | 4.1 ± 3.3 | 1.8 ± 2.7 | 0.001 | |
| Nasal PR/UD (degree/100 µm) | 7.8 ± 7.4 | 7.0 ± 6.1 | 0.588 | |
| Inferior PR/UD (degree/100 µm) | 5.6 ± 3.7 | 4.2 ± 4.5 | 0.088 | |
| Microvasculature by OCTA | VVDr | 1.703 ± 0.224 | 1.682 ± 0.202 | 0.183 |
| VVDs | 2.903 ± 0.511 | 2.867 ± 0.448 | 0.167 | |
| VVDd | 4.077 ± 0.436 | 4.046 ± 0.373 | 0.418 | |
| Microstructure by UHR-OCT | TRT-annulus (µm) | 269.2 ± 13.6 | 268.6 ± 13.6 | 0.723 |
| mRNFL-annulus (µm) | 33.6 ± 4.8 | 33.7 ± 4.7 | 0.911 | |
| GCIPL-annulus (µm) | 65.8 ± 7.6 | 65.2 ± 7.0 | 0.546 | |
| Microstructure by Zeiss OCT | GCIPL (µm) | 76.3 ± 10.0 | 75.9 ± 9.9 | 0.004 |
| pRNFL (µm) | 90.6 ± 13.1 | 89.9 ± 12.8 | 0.214 | |
| Microcirculation by RFIa | Arteriolar RBF (nl/s) | 2.56 ± 0.80 | 2.94 ± 0.98 | 0.016 |
| Venular RBF (nl/s) | 2.49 ± 0.83 | 2.87 ± 1.00 | 0.013 | |
| RTP (nl/s/mm3) | 2.43 ± 0.88 | 2.76 ± 1.00 | 0.042 | |
LCLA, low contrast letter acuity; BCVA, best corrected high contrast visual acuity; PERG, pattern electroretinogram; mRNFL, macular retinal nerve fiber layer; pRNFL, peripapillary retinal nerve fiber layer; PS-OCT, polarization-sensitive optical coherence tomography; PR/UD, phase retardation per unit depth; OCTA, optical coherence tomography angiography; VVDr, volumetric vessel density of retinal vascular network; VVDs, volumetric vessel density of superficial vascular plexus; VVDd, volumetric vessel density of deep vascular plexus; UHR-OCT, ultra-high-resolution optical coherence tomography; TRT, total retinal thickness; RNFL, retinal nerve fiber layer; GCIPL, ganglion cell, and inner plexiform layer; RFI, retinal function imager; RBF, retinal blood flow; RTP, retinal tissue perfusion.
Bold P value represents < 0.05.
Only one eye of each patient was imaged.