Table 5.
Comparisons of all the Variables Between Baseline and 1 Year Follow-Up in Multiple Sclerosis Patients With and Without ON Eyes
| Baseline | 1-y Follow-Up | ||||||
|---|---|---|---|---|---|---|---|
| Variables | ON (17 Eyes) | NON (71 Eyes) | P Values | ON (17 Eyes) | NON (71 Eyes) | P Values | |
| Vision function by LCLA test | 2.5% LCLA | 48.9 ± 12.8 | 51.5 ± 7.3 | 0.557 | 47.6 ± 13.6 | 52.6 ± 8.0 | 0.224 |
| 1.25% LCLA | 21.5 ± 13.0 | 27.7 ± 9.2 | 0.141 | 22.4 ± 14.1 | 27.6 ± 9.0 | 0.200 | |
| RGC function by PERG test | Amplitude (nV) | 719.0 ± 248.2 | 1027.8 ± 386.4 | <0.001 a | 699.0 ± 271.4 | 1033.6 ± 351.6 | <0.001 a |
| Latency (ms) | 48.4 ± 4.5 | 51.4 ± 2.8 | <0.001 a | 51.0 ± 5.7 | 51.1 ± 3.0 | 0.956 | |
| pRNFL birefringence by PS-OCT b | Average PR/UD (degree/100 µm) | 3.9 ± 2.7 | 4.4 ± 2.5 | 0.530 | 3.5 ± 4.2 | 3.7 ± 2.5 | 0.880 |
| Temporal PR/UD (degree/100 µm) | 3.3 ± 3.4 | 5.6 ± 3.9 | 0.051 | 2.3 ± 2.7 | 3.3 ± 3.0 | 0.299 | |
| Superior PR/UD (degree/100 µm) | 2.7 ± 4.4 | 4.6 ± 2.7 | 0.151 | 1.0 ± 3.6 | 2.2 ± 2.3 | 0.309 | |
| Nasal PR/UD (degree/100 µm) | 7.3 ± 7.8 | 8.0 ± 7.3 | 0.798 | 7.6 ± 5.8 | 6.8 ± 6.3 | 0.728 | |
| Inferior PR/UD (degree/100 µm) | 5.5 ± 4.2 | 5.6 ± 3.6 | 0.932 | 2.7 ± 5.8 | 4.8 ± 3.8 | 0.263 | |
| Microvasculature by OCTA | VVDr | 1.915 ± 0.293 | 1.653 ± 0.173 | 0.006 a | 1.830 ± 0.276 | 1.649 ± 0.166 | 0.082 |
| VVDs | 3.429 ± 0.658 | 2.781 ± 0.384 | 0.002 a | 3.210 ± 0.603 | 2.787 ± 0.366 | 0.025 a | |
| VVDd | 4.287 ± 0.609 | 4.028 ± 0.374 | 0.163 | 4.180 ± 0.484 | 4.016 ± 0.341 | 0.381 | |
| Microstructure by UHR-OCT | TRT-annulus (µm) | 255.7 ± 15.8 | 272.3 ± 10.9 | <0.001 a | 257.2 ± 15.9 | 271.4 ± 11.4 | <0.001 a |
| mRNFL-annulus (µm) | 28.9 ± 5.2 | 34.8 ± 4.0 | <0.001 a | 29.2 ± 5.5 | 34.8 ± 3.7 | <0.001 a | |
| GCIPL-annulus (µm) | 57.3 ± 7.7 | 67.8 ± 6.0 | <0.001 a | 58.4 ± 7.2 | 66.9 ± 5.9 | <0.001 a | |
| Microstructure by Zeiss OCT | GCIPL (µm) | 65.9 ± 9.7 | 78.9 ± 8.3 | <0.001 a | 65.4 ± 10.1 | 78.4 ± 8.1 | <0.001 a |
| pRNFL (µm) | 79.3 ± 11.5 | 93.5 ± 11.9 | <0.001 a | 80.7 ± 12.0 | 92.1 ± 12.0 | <0.001 a | |
| Microcirculation by RFI b | Arteriolar RBF (nl/s) | 2.33 ± 0.75 | 2.62 ± 0.81 | 0.280 | 2.79 ± 0.78 | 2.98 ± 1.03 | 0.549 |
| Venular RBF (nl/s) | 2.22 ± 0.73 | 2.55 ± 0.85 | 0.222 | 2.65 ± 0.58 | 2.93 ± 1.08 | 0.307 | |
| RTP (nl/s/mm3) | 2.57 ± 1.18 | 2.39 ± 0.81 | 0.657 | 2.92 ± 0.92 | 2.72 ± 1.03 | 0.588 | |
ON, optic neuritis; EDSS, Expanded Disability State Scale; LCLA, low contrast letter acuity; PERG, pattern electroretinogram; pRNFL, peripapillary retinal nerve fiber layer; PS-OCT, polarization-sensitive optical coherence tomography; PR/UD, phase retardation per unit depth; OCTA, optical coherence tomography angiography; VVDr, volumetric vessel density of retinal vascular network; VVDs, volumetric vessel density of superficial vascular plexus; VVDd, volumetric vessel density of deep vascular plexus; UHR-OCT, ultra-high-resolution optical coherence tomography; TRT, total retinal thickness; RNFL, retinal nerve fiber layer; GCIPL, ganglion cell inner plexiform layer; RFI, retinal function imager; RBF, retinal blood flow; RTP, retinal tissue perfusion.
Δ, differences between baseline and 1-year follow-up.
With bold values, P < 0.05 baseline versus 1-year follow-up. Bold P value represents < 0.05.
Only one eye of each patient was imaged.