Table 6.
Comparisons of the Differences of All the Variables Between Baseline and 1 Year Follow-Up in Patients With Multiple Sclerosis With and Without ON Eyes
| ON Eyes Versus Non-On Eyes | ||||
|---|---|---|---|---|
| Δ Variables | ON (17 Eyes) | Non-On (71 Eyes) | P Values | |
| Clinical index | EDSS scores | 0.0 ± 0.1 | 0.1 ± 0.4 | 0.208 |
| MOPP (mm Hg) | −1.6 ± 6.3 | 0.1 ± 5.9 | 0.451 | |
| Vision function by LCLA test | 2.5% LCLA | −2.1 ± 6.2 | 1.3 ± 7.4 | 0.038 |
| 1.25% LCLA | 0.4 ± 7.6 | −0.2 ± 6.1 | 0.741 | |
| RGC function by PERG test | Amplitude (nV) | −17.7 ± 267.3 | −2.6 ± 406.3 | 0.503 |
| Latency (ms) | 2.1 ± 3.1 a | −0.9 ± 2.8 | <0.001 | |
| pRNFL birefringence by PS-OCT b | Average PR/UD (degree/100 µm) | −0.4 ± 5.5 | −0.8 ± 3.5 | 0.799 |
| Temporal PR/UD (degree/100 µm) | −1.0 ± 5.1 | −2.1 ± 4.7a | 0.510 | |
| Superior PR/UD (degree/100 µm) | −1.7 ± 6.0 | −2.0 ± 3.2a | 0.851 | |
| Nasal PR/UD (degree/100 µm) | 0.2 ± 10.4 | −1.6 ± 9.2 | 0.608 | |
| Inferior PR/UD (degree/100 µm) | −2.7 ± 6.9 | −1.0 ± 4.5 | 0.425 | |
| Microvasculature by OCTA | VVDr | −0.078 ± 0.221a | −0.014 ± 0.110 | 0.292 |
| VVDs | −0.185 ± 0.356 | −0.025 ± 0.235 | 0.168 | |
| VVDd | −0.138 ± 0.642 | −0.027 ± 0.329 | 0.481 | |
| Microstructure by UHR-OCT | TRT-annulus (µm) | 1.2 ± 6.4 | 0.0 ± 5.4 | 0.484 |
| mRNFL-annulus (µm) | 0.3 ± 2.3 | 0.3 ± 2.7 | 0.885 | |
| GCIPL-annulus (µm) | 0.7 ± 1.8 | −0.2 ± 3.6 | 0.145 | |
| Microstructure by Zeiss OCT | GCIPL (µm) | −0.9 ± 2.8 | −0.4 ± 1.2a | 0.482 |
| pRNFL (µm) | 1.0 ± 5.5 | −1.0 ± 3.6a | 0.125 | |
| Microcirculation by RFI b | Arteriolar RBF (nl/s) | 0.43 ± 0.81 | 0.44 ± 1.13 | 0.980 |
| Venular RBF (nl/s) | 0.40 ± 0.81 | 0.42 ± 1.16 | 0.945 | |
| RTP (nl/s/mm3) | 0.34 ± 1.19 | 0.33 ± 1.02 | 0.979 | |
ON, optic neuritis; EDSS, Expanded Disability State Scale; LCLA, low contrast letter acuity; PERG, pattern electroretinogram; mRNFL, macular retinal nerve fiber layer; pRNFL, peripapillary retinal nerve fiber layer; PS-OCT, polarization-sensitive optical coherence tomography; PR/UD, phase retardation per unit depth; OCTA, optical coherence tomography angiography; VVDr, volumetric vessel density of retinal vascular network; VVDs, volumetric vessel density of superficial vascular plexus; VVDd, volumetric vessel density of deep vascular plexus; UHR-OCT, ultra-high-resolution optical coherence tomography; TRT, total retinal thickness; RNFL, retinal nerve fiber layer; GCIPL, ganglion cell inner plexiform layer; RFI, retinal function imager; RBF, retinal blood flow; RTP, retinal tissue perfusion.
Δ, differences between baseline and 1-year follow-up.
With bold values, P < 0.05 baseline versus 1-year follow-up. Bold P value represents < 0.05.
Only one eye of each patient was imaged.