Table 2.
Top Pathways and Up- or Downregulated Proteins in the PDR Group
| Pathway | Upregulated Proteins | Downregulated Proteins |
|---|---|---|
| Complement and coagulation cascades | C4BPA, C5, C9, F13B, FGA, FGB, FGG, KLKB1, KNG1, SERPIND1, VTN | |
| Platelet activation | FGA, FGB, FGG, ITGA2 | |
| ECM-receptor interaction | FN1, ITGA2, VTN | COL2A1, COL9A1, COL9A2, SDC4, TNR |
| Focal adhesion | FN1, ITGA2, VTN | COL2A1, COL9A1, COL9A2, SDC4, TNR |
| Protein digestion and absorption | MEP1A | COL2A1, COL9A1, COL9A2 |
| Human papillomavirus infection | FN1, ITGA2, VTN, MFNG | COL2A1, COL9A1, COL9A2, SDC4, TNR |
| PI3K-Akt signaling pathway | FN1, ITGA2, VTN | COL2A1, COL9A1, COL9A2, TNR |
| Cholesterol metabolism | APOA1, APOA2, APOA4, APOB, APOC1, APOC2, APOC3, LPA | LDLR, LRP2, SORT1 |
| PPAR signaling pathway | ADIPOQ, APOA1, APOA2, APOC3, FABP1 | |
| Fat digestion and absorption | APOA1, APOA4, APOB, FABP1 | |
| Vitamin digestion and absorption | APOA1, APOA4, APOB |