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. 2021 Apr;13(4):2242–2254. doi: 10.21037/jtd-20-3069

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2021 Journal of Thoracic Disease. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Identification and validation of hub genes. Scatter plot to visualize the relationship between hub genes ECM2 (A), GLT8D2 (B) and the value of mPAP. Expression levels of hub genes ECM2 (C), GLT8D2 (D) between different PAH subtypes. Kruskal-Wallis H test was used to evaluate the statistical difference. The different letter marks significant difference. Validation of hub genes through independent datasets GSE48149 (E) and GSE113439 (F). Wilcoxon signed-rank test was used to evaluate the statistical significance of differences. mPAP, mean pulmonary artery pressure; PAH, pulmonary artery hypertension.