Table 1. Candidate hub gene in the pink module.

Gene	GS	MM	Spearman correlation coefficient	P.val	P.adj
GLT8D2	0.632671	0.850674	0.443	0.0006	0.01
ECM2	0.64762	0.855973	0.407	0.0019	0.015
FGR	−0.6473	−0.82583	−0.323	0.0152	0.061
PYGL	−0.65238	−0.84857	−0.324	0.015	0.061
TALDO1	−0.70311	−0.83711	−0.298	0.0255	0.082
ANTXR1	0.667129	0.804286	0.212	0.1169	0.312
CSF3R	−0.74587	−0.83269	−0.192	0.1558	0.356
PDE7B	0.698733	0.821378	0.18	0.1849	0.361
S100A9	−0.69232	−0.8832	−0.173	0.2029	0.361
RNASE2	−0.73807	−0.83456	−0.158	0.2437	0.39
AQP9	−0.60439	−0.80104	−0.149	0.2738	0.398
S100A8	−0.61492	−0.81337	−0.135	0.3227	0.43
MGAM	−0.67065	−0.84404	−0.088	0.5178	0.637
NLRP12	−0.64292	−0.82498	−0.05	0.716	0.818
GLT1D1	−0.67621	−0.82705	−0.006	0.9653	0.987
RIPOR2	−0.63329	−0.82724	0.002	0.987	0.987

Genes in pink module with MM >0.8, GS >0.2. Spearman correlation calculated the correlation coefficient between gene expression and mPAP. FDR was used for multiple testing correction. MM, module membership; GS, gene significance; mPAP, mean pulmonary artery pressure; FDR, false discovery rate.