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. 2021 Apr;13(4):2447–2459. doi: 10.21037/jtd-21-212

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2021 Journal of Thoracic Disease. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

PMC Copyright notice

CircRNA 010567-siRNA protected H9c2 cells against hypoxia-induced apoptosis. CircRNA 010567-siRNA, control-siRNA, miR-141 inhibitor, or inhibitor control were transfected into hypoxia-induced H9c2 cells. (A) The viability of cardiomyocytes was assessed using the MTT assay; (B) Fow cytometry analysis of apoptotic cardiomyocytes; (C) statistical analysis of apoptotic cells; (D) detection of caspase-3 activity. Results were presented as mean ± SD. **, P<0.01 vs. control; ^##, P<0.01 vs. hypoxia + control-siRNA; ^&&, P<0.01 vs. hypoxia + circ-siRNA + inhibitor control.