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. 2021 Apr;13(4):2532–2550. doi: 10.21037/jtd-21-22

Figure 1.

Figure 1

A metabolomics-centric view of the metabolic pathways. Genetic variations lead to changes in gene expression (transcriptome) which affect protein variations (proteome). The metabolic phenotype is influenced by many factors. In turn, variations in metabolism can modify genomic, transcriptomic and proteomic outputs.