Landscape of somatic mutations in CRCLM samples. Figure left: proportion of gene mutations. Figure right: significance of highfrequencymutations. Figure right: sample mutation frequency. The types of mutations are shown, including (I) non-synonymous mutations (green), (II) shear site mutations (yellow), (III) causes code shift insertion (purple), and (IV) causes code shift deletion (red). CVRCLM, colorectal cancer liver metastasis.