Figure 2.

INI1-deficient tumor histology. (A) Lower power magnification (H&E, 30×) showing: INI1-deficient tumor within pancreas (arrow) and surrounding background pancreatic tissue (arrowhead). (B) At higher power magnification (H&E, 300×), the INI1-deficient tumor cells (arrow) are more readily visible, beside infiltrating lymphocytes (bracket). The predominant morphology was epithelioid. (C) INI1 immunostain at 300× magnification shows preserved INI1 staining in normal pancreatic cells, fibroblasts, and lymphocytes (bracket), which serve as internal positive controls, while the tumor cells (arrow) are not staining. (D) The INI1 immunostain at 300× magnification shows non-staining tumor cells (arrow) infiltrating pancreatic tissue with well stained pancreatic ductules and background fibroblasts and lymphocytes (bracket). (E) Lastly, arrowheads depict the pink cytoplasmic inclusions and displaced nuclei characteristic of rhaboid morphology.