Table 1.

Association between TLRs SNPs and autoimmune diseases.

Disease	Gene	Rs#	Sample population	Number of patients	Number of controls	OR	p valune	Ref
Type 1 Diabetes Mellitus	TLR1	rs4833095	Chinese Han population	429	300	2.22	0.03	(53)
		rs5743612	Chinese Han population	429	300	1.98	0.01	(53)
	TLR2	rs3804100	Korean population	407	1142	1.7	≤0.05	(52)
	TLR3	rs5743313	South African Blacks	79	74	1.1	0.042	(57)
		rs5743315	South African Blacks	79	74	0.68	0.03	(57)
		rs3775291	Brazil	449	507	2.3	0.004	(56)
		rs13126816	Brazil	449	507	2.1	10^-4	(56)
		rs5743313	Brazil	449	507	NO	0.561	(56)
		rs11721827	Brazil	449	507	NO	0.053	(56)
Graves' Disease	TLR5	rs5744174	Chinese Cantonese population	332	351	0.63	0.003	(64)
	TLR1	rs5743565	Chinese Cantonese population	332	351	0.72	0.005	(64)
	TLR7	rs179010	Chinese Cantonese population	332	351	0.64	0.004	(64)
	TLR4	rs10759932	Korean	60	183	2.06	0.015	(65)
		rs1927911	Korean	60	183	1.96	0.009	(65)
	TSHR	rs2284720	North American Caucasian	225	183	1.6	0.03	(66)
Systemic Lupus Erythematosus	TLR9	rs351240	Chinese Han population	430	424	NO	≤0.05	(78)
	TLR7	rs3853839	Taiwanese population	795	1162	2.82	0.01	(79)
	TLR8	rs3764880	Taiwanese population	795	1162	2.91	0.0173	(79)
	TLR3	rs3775291	Danish	143	432	1.53	0.006	(80)
	TLR8	rs3764879	Danish	143	432	1.47	0.013	(80)
	TLR9	rs352143	Danish	143	432	1.46	< 0.02	(80)
Rheumatoid Arthritis	TLR8	rs5741883	European population	319	319	0.88	0.02	(93)
	TLR9	rs187084	Swedish patients	2158	1068	NO	NS	(94)
	TLR9	rs187084	Dutch	378	294	0.92	0.48	(94)
	TLR9	rs187084	UK	406	430	NO	NS	(94)
	TLR9	rs187084	Turkish population	100	100	1.85	0.01	(95)
	TRAF5	rs7514863	British	1273	2463	1.2	0.005	(96)
Multiple Sclerosis	SOCS	rs243324	Spain population	3919	4003	1.13	0.00006	(108)
	TLR9	rs5743836	Portuguese population	165	165	NO	0.274	(110)
	TLR9	rs352162	white Spanish individuals	574	807	0.75	0.024	(109)
	TLR9	rs187084	white Spanish individuals	574	807	1.66	0.028	(109)