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. 2021 Apr 26;12:653887. doi: 10.3389/fphar.2021.653887

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Copyright © 2021 Ye, Liu, Wu, Han, Wang, Yu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Meta-analysis and migration analysis of the effect of berberine on homeostasis model assessment of insulin resistance. Forest plot illustrates the differences in changes in homeostasis model assessment of insulin resistance in adults with metabolic disease who did or did not receive berberine in 5 trials (n = 471). The mean difference (blue squares), 95% CI (horizontal lines through blue squares), and pooled-effect sizes (green diamonds) were presented using fixed-effects inverse-variance models.