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. 2021 Apr 26;12:666541. doi: 10.3389/fphar.2021.666541

TABLE 1.

Information about the studied polymorphisms.

Gene name ID gene rs# Alternative Ancestral/reference allele MAF b Primer_AlleleX Primer_AlleleY
AANAT–(serotonin-N-acetyltransferase) ID:15 rs8150 G > C, A a G C = 0.3201 AAT​ATT​ATT​TAA​TCC​ATG​AGA​CAT​CGT​CCA ATT​TAA​TCC​ATG​AGA​CAT​CGT​CCG
rs3760138 G > T, A a G G = 0.4781 GGG​GTG​CAG​GAT​GGG​GTG​TA GGG​TGC​AGG​ATG​GGG​TGT​G
rs4238989 C > G C C = 0.4423 CCC​TCG​GAG​TCT​TGG​ACA​AG CCC​TCG​GAG​TCT​TGG​ACA​AC
ASMT–acetyloserotonin-O-methyltransferase ID:438 rs4446909 G > A G A = 0.286 GAA​CTG​ATC​CCA​AAC​CAA​TAT​GCT​C AGA​ACT​GAT​CCC​AAA​CCA​ATA​TGC​TT
rs5989681 G > C, A a G C = 0.302 AGG​GGA​TCA​CAA​AGC​GTG​TGG​T GGG​ATC​ACA​AAG​CGT​GTG​GC
MTNR1B–melatonin receptor 1B ID:4544 rs4753426 C > T, A a T T = 0.4980 AAT​ACA​ACA​TAT​TTG​TGA​TTA​ATC​CAT​GCC CAA​TAC​AAC​ATA​TTT​GTG​ATT​AAT​CCA​TGC​T
rs10830963 C > G,T a C G = 0.2883 GGC​AGT​TAC​TGG​TTC​TGG​ATA​GG GGC​AGT​TAC​TGG​TTC​TGG​ATA​GC
rs156244 c C > A,G a ,T a C C = 0.0010 ATT​AAC​GTC​ATC​ATT​AAA​ATA​ATA​AAA​CCC​AAA AAC​GTC​ATC​ATT​AAA​ATA​ATA​AAA​CCC​AAC
rs6483221 C > T,A a ,G a C C = 0.1968 AAA​AGA​TCA​GAT​ATG​TTA​ACA​TTC​TTG​ATA​AG CAA​AAG​ATC​AGA​TAT​GTT​AAC​ATT​CTT​GAT​AAA
MTNR1A- melatonin receptor 1A ID:4543 rs2119882 C > T T = 0.3837 CCC​CAA​TCC​CAT​TTC​GCA​TTT​GG CCC​CAA​TCC​CAT​TTC​GCA​TTT​GA
rs12506228 C > A C A = 0.2913 GAA​ACT​AAG​ATG​GGT​AGA​AAG​TCA​GAT AAA​CTA​AGA​TGG​GTA​GAA​AGT​CAG​AG
CYP1A2–cytochrome P450 1A2 ID:1544 rs2470890 T > C T C = 0.35424 CAG​AAT​GGT​GGT​GTC​TTC​TTC​AA CAG​AAT​GGT​GGT​GTC​TTC​TTC​AG
rs762551 C > A, G a C C = 0.35424 CCA​TCT​ACC​ATG​CGT​CCT​GT CCA​TCT​ACC​ATG​CGT​CCT​GG
rs2472304 A > G G G = 0.4006 GTA​GAC​TGA​ACA​AAC​AAC​CTG​GGT​T AGA​CTG​AAC​AAA​CAA​CCT​GGG​TC
CYP1B1–cytochrome P450 1B1 ID:1545 rs1056836 G > C, (exon) Leu432Val G C = 0.4434 GTG​GTC​TGT​GAA​TCA​TGA​CCC​AC GTG​GTC​TGT​GAA​TCA​TGA​CCC​AG
a

Allele not identified in studied population.

b

1000GENOMES Europe population based on GRCh38. p12 version.

c

Variant not polymorphic in studied population.