TABLE 4.
Differentially expressed genes (DEGs) in studied models.
| Model | Total DEGs, p < 0.05, FC > 2 | Up | Down | DAVID/KEGG a | Up | Down |
|---|---|---|---|---|---|---|
| Clinical model | ||||||
| Agomelatine (+) vs. HC | 4648 | 2217 | 2431 | 1275 | 542 | 733 |
| Agomelatine (−) vs. HC | 3999 | 567 | 3432 | 803 | 152 | 651 |
| Common and different genes (Venn diagram) | 3224 | 1688 | 1536 | 947 | 402 | 545 |
| Cell culture model | ||||||
| Melatonin (+) vs. melatonin (−) | 18,489 | 762 | 17727 | 13,105 | 762 | 5343 |
FC, fold change; PBMC, peripheral blood mononuclear cells; HN, hippocampal neurons.
a
Functionally known by the DAVID/KEGG database.