TABLE 6.
KEGG pathways pass after FDR correction.
| KEGG pathway | Genes in pathway | p-value | FDR | |
|---|---|---|---|---|
| Agomelatine (+) vs. HC | Downregulated genes | |||
| hsa04666: Fc gamma R-mediated phagocytosis | AKT2, LIMK2, DOCK2, WASF2, HCK, CRK, MAPK3, RAC2, PLPP2, GAB2, ARPC1B, LIMK2, WAS, RAF1, PIK3CD | 0.0001 | 0.0161 | |
| hsa04062: chemokine signaling pathway | AKT2, DOCK2, ADCY1, GNB2, IKBKG, SHC1, HCK, CRK, MAPK3, CCL2, PRKACA, CCR4, RAC2, CXCR1, NFKBIB, CCR1, WAS, RAF1, PIK3CD, ARRB1, STAT3 | 0.0002 | 0.0161 | |
| hsa04380: osteoclast differentiation | AKT2, LILRB3, TYK2, IKBKG, IL1B, LILRA1, MAPK3, NFKB2, LILRA4, FOS, GAB2, LILRB4, LILRA3, PIK3CD, TGFB1, JUNB, LILRA2 | 0.0002 | 0.0161 | |
| hsa04722: neurotrophin signaling pathway | AKT2, NTRK1, MAP3K5, SHC1, CRK, MAPK3, NTRK2, MAPKAPK2, BAX, RAPGEF1, NFKBIB, RAF1, PIK3CD, NGFR, SH2B1 | 0.0008 | 0.0478 | |
| Agomelatine (-) vs. HC | Downregulated genes | |||
| hsa04080: neuroactive ligand–receptor interaction | AVPR2, GABRQ, GRIN2C, GLP2R, TACR1, GPR50, MC5R, PRSS3, VIPR2, LPAR2, GRIK5, NPY5R, CHRNB4, CRHR2, RXFP2, ADORA1, SCTR, GRIA1, MC3R, RXFP3, TRHR, APLNR, PTGER1, GABRE, GABRR3, GHRHR, VIPR2, GRIN2C, NMUR2, GLRA1, GRIN3A | 6.8960E−08 | 1.5378E−05 | |
| hsa04972: pancreatic secretion | ADCY6, PLA2G5, CELA2A, PLA2G12B, GNAS, ATP1B2, PLA2G2A, ATP2B3, ATP2A1, SCTR, ATP2B2, PRSS3 | 0.0002 | 0.0221 | |
| Unique pathways for agomelatine treatment | Downregulated genes | |||
| hsa04062: chemokine signaling pathway | AKT2, DOCK2, ADCY1, GNB2, IKBKG, SHC1, HCK, CRK, MAPK3, CCL2, PRKACA, CCR4, RAC2, CXCR1, NFKBIB, CCR1, WAS, RAF1, PIK3CD, ARRB1, STAT3 | 3.3486E−06 | 0.0007 | |
| hsa04666: Fc gamma R-mediated phagocytosis | AKT2, LIMK2, DOCK2, HCK, CRK, MAPK3, RAC2, PLPP2, GAB2, ARPC1B, LIMK2, WAS, RAF1, PIK3CD | 1.9636E−05 | 0.0020 | |
| hsa04380: osteoclast differentiation | AKT2, LILRB3, IKBKG, IL1B, LILRA1, MAPK3, NFKB2, LILRA4, GAB2, LILRB4, LILRA3, PIK3CD, TGFB1, JUNB | 0.0004 | 0.0277 | |
| hsa05220: chronic myeloid leukemia | AKT2, CDKN1A, GAB2, RAF1, PIK3CD, IKBKG, SHC1, CRK, MAPK3, TGFB1 | 0.0006 | 0.0309 | |
| hsa05020: prion diseases | ELK1, BAX, NOTCH1, IL1B, MAPK3, STIP1, PRKACA | 0.0008 | 0.0327 | |
| hsa05145: toxoplasmosis | AKT2, HSPA6, BIRC8, IKBKG, IL10RB, LAMA2, MAPK3, MYD88, NFKBIB, TLR4, STAT3, TGFB1 | 0.0011 | 0.0361 | |
| hsa05166: HTLV-I infection | AKT2, ITGB2, ELK1, ADCY1, ZFP36, IKBKG, ATF3, LTBR, NFKB2, PRKACA, CDKN1A, BAX, ANAPC2, PIK3CD, DVL3, PDGFB, TGFB1, DVL1, VAC14 | 0.0020 | 0.0488 | |
| hsa04722: neurotrophin signaling pathway | AKT2, BAX, NFKBIB, RAPGEF1, MAP3K5, RAF1, PIK3CD, SHC1, CRK, MAPK3, SH2B1, MAPKAPK2 | 0.0022 | 0.0488 | |
| hsa05142: Chagas disease (American trypanosomiasis) | AKT2, MYD88, ADCY1, TLR4, CFLAR, PIK3CD, IKBKG, IL1B, MAPK3, TGFB1, CCL2 | 0.0024 | 0.0488 | |
| hsa05140: leishmaniasis | ELK1, ITGB2, PTPN6, MYD88, NFKBIB, TLR4, IL1B, MAPK3, TGFB1 | 0.0024 | 0.0488 | |
| hsa04668: TNF signaling pathway | AKT2, CREB5, MAP3K5, CFLAR, PIK3CD, IKBKG, TNFRSF1B, IL1B, MAPK3, CCL2, JUNB | 0.0029 | 0.0547 | |
| hsa05161: hepatitis B | AKT2, CREB5, ELK1, IKBKG, MAPK3, CDKN1A, BAX, MYD88, TLR4, RAF1, PIK3CD, STAT3, TGFB1 | 0.0033 | 0.0553 |