Table 3. Angiographic and electrocardiographic outcomes and serial echocardiographic findings.
| Variables | Tacrolimus (n = 151) | Control (n = 165) | Odds ratio (95% CI) | p value |
| Post-PCI epicardial coronary flow | ||||
| TIMI flow grade, mean ± SD | 2.89 ± 0.44 | 2.87 ± 0.39 | 1.15 (0.67-1.99) | 0.606 |
| TIMI grade 2 or 3, % (n) | 96.7% (146) | 98.2% (162) | 0.54 (0.13-2.30) | 0.406 |
| TIMI grade 3, % (n) | 92.7% (139) | 88.5% (146) | 1.66 (0.76-3.61) | 0.200 |
| Post-PCI microcirculatory status | ||||
| TMP grade, mean ± SD | 2.54 ± 0.71 | 2.23 ± 0.77 | 1.78 (1.29-2.46) | < 0.001 |
| TMP grade 2 or 3, % (n) | 92.7% (140) | 84.1% (138) | 2.40 (1.14-5.02) | 0.021 |
| 90-min STR, mean ± SD | 0.67 ± 0.29 | 0.61 ± 0.33 | 4.94 (2.30-10.59) | < 0.001 |
| Persistent ST elevation, % (n) | 5.7% (9) | 11% (18) | 0.49 (0.21-1.18) | 0.112 |
| Composite endpoint of TIMI 3 flow, TMP grade 3, or complete 90-min STR | 90.7% (137) | 85.5% (141) | 1.94 (0.84-4.47) | 0.113 |
| 3-month echocardiography | ||||
| 2D LVEF (%), mean ± SD | 59.55 ± 11.67 | 61.03 ± 11.38 | 0.99 (0.98-1.02) | 0.929 |
| LVEDD (mm) | 49.57 ± 11.57 | 49.20 ± 10.63 | 1.00 (0.98-1.03) | 0.802 |
| LVESD (mm) | 33.63 ± 9.59 | 33.75 ± 8.54 | 1.01 (0.98-1.04) | 0.551 |
| 3D LVEF (%), mean ± SD | 57.66 ± 9.95 | 58.56 ± 10.36 | 0.99 (0.97-1.02) | 0.564 |
| LVEDV (mm3) | 89.28 ± 24.53 | 89.05 ± 25.37 | 1.00 (0.99-1.01) | 0.55 |
| LVESV (mm3) | 39.14 ± 18.53 | 37.90 ± 19.31 | 1.01 (0.99-1.02) | 0.472 |
| GLS by 2D-STE (%) | -15.92 ± 3.84 | -16.27 ± 4.20 | 0.97 (0.90-1.05) | 0.439 |
| RLS by 2D-STE (%) | -14.15 ± 4.95 | -14.18 ± 5.52 | 0.99 (0.94-1.05) | 0.778 |
| E/A ratio | 1.03 ± 0.56 | 1.42 ± 2.95 | 0.82 (0.54-1.24) | 0.348 |
| Grade of LVDD, mean ± SD | 1.68 ± 0.63 | 1.72 ± 0.61 | 0.83 (0.51-1.35) | 0.444 |
| % of grade 2 or 3 LVDD, % (n) | 65.4% (98) | 65.9% (108) | 0.98 (0.52-1.84) | 0.945 |
| TAPSE (mm) | 22.86 ± 5.32 | 22.81 ± 5.13 | 1.01 (0.96-1.07) | 0.694 |
| 9-month echocardiography | ||||
| 2D LVEF (%), mean ± SD | 61.27 ± 10.63 | 60.94 ± 11.04 | 1.00 (0.98-1.03) | 0.731 |
| LVEDD (mm) | 51.52 ± 6.54 | 50.59 ± 6.15 | 1.01 (0.98-1.03) | 0.550 |
| LVESD (mm) | 34.69 ± 7.34 | 33.95 ± 7.14 | 1.01 (0.98-1.04) | 0.659 |
| 3D LVEF (%), mean ± SD | 61.03 ± 8.64 | 57.96 ± 9.23 | 1.04 (1.003-1.08) | 0.031 |
| LVEDV (mm3) | 91.59 ± 26.03 | 92.64 ± 23.92 | 1.00 (0.99-1.01) | 0.769 |
| LVESV (mm3) | 36.73 ± 17.48 | 40.22 ± 18.94 | 0.99 (0.98-1.01) | 0.277 |
| GLS by 2D-STE (%) | -16.29 ± 3.36 | -16.12 ± 3.47 | 1.03 (0.94-1.12) | 0.564 |
| RLS by 2D-STE (%) | -14.78 ± 4.59 | -14.89 ± 4.13 | 1.00 (0.93-1.08) | 0.929 |
| E/A ratio | 0.95 ± 0.37 | 1.01 ± 0.49 | 0.71 (0.33-1.51) | 0.375 |
| Grade of LVDD, mean ± SD | 1.41 ± 0.65 | 1.69 ± 0.62 | 0.50 (0.30-0.84) | 0.009 |
| % of grade 2 or 3 LVDD, % (n) | 47.2% (71) | 63.1% (104) | 0.52 (0.28-0.99) | 0.048 |
| TAPSE (mm) | 23.25 ± 4.43 | 22.70 ± 5.28 | 1.02 (0.96-1.09) | 0.507 |
Data are expressed as mean ± standard deviation (SD) or % (n).
CI, confidence interval; E/A ratio, the ratio of the early (E) to late (A) ventricular filling velocities; GLS, global longitudinal strain; LVDD, LV diastolic dysfunction; LVEDD, left ventricular end-diastolic diameter; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systolic diameter; LVESV, left ventricular end-systolic volume; PCI, percutaneous coronary intervention; RLS, regional longitudinal strain; STR, ST-segment resolution; echo, echocardiography; TAPSE, tricuspid annular plane systolic excursion; TIMI, Thrombolysis In Myocardial Infarction; TMP, TIMI myocardial performance; 2D or 3D, 2- or 3-dimentional echocardiography; 2D-STE, 2D speckle tracking echocardiography.