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. 2021 Apr;10(4):1841–1856. doi: 10.21037/tlcr-21-299

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2021 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Let-7b-3p exerted tumor-suppressor effects via the BRF2-mediated MAPK/ERK pathway in LUAD. (A,B) Restoration of BRF2 rescued the invasive and migratory phenotypes induced by let-7b-3p. The cells were stained with crystal violet. Scale bars in (A) and (B) represent 100 µm. (C) The variance of protein expression induced by let-7b-3p was partly restored by BRF2. (D) KEGG pathway enrichment analysis. (E) The expression of PI3K/AKT and MAPK pathway-related proteins were determined by WB. Data are presented as mean ± SD according to Student’s t-test (*, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001; ns, no significance). BRF2, TFIIB-related factor 2; KEGG, Kyoto Encyclopedia of Genes and Genomes.