Figure 2.

TAM targeting in lung cancer. Induction of TLR4 and IFN-γ receptor by their agonists skewed TAMs into anti-tumoral M1 phenotype. miRNA-130a by targeting PPAR-γ transcription factor regulates M1-related genes expression in TAMs in lung cancer. Targeting CSF1 and IL-6 by specific inhibitors prevents M2-polarized TAMs and suppresses lung cancer. Siltuximab by inhibition of STAT3 signaling prevents lung tumor growth. CSF, colony stimulating factor; IRF, interferon regulatory factor; PA-MSHA, pseudomonas aeruginosa-mannose-sensitive hemagglutinin; PPAR-γ, peroxisome proliferator-activated receptor gamma; STAT, signal transducer and activator of transcription.