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. 2021 Apr;10(4):1857–1872. doi: 10.21037/tlcr-21-303

Figure 1.

Figure 1

EGFR-TKI intrinsic drug-resistant EGFR activating mutant lung cancer cells are more sensitive to ferroptosis inducers. (A) HCC4011, H1993, H1650 cells were divided into two groups: treatment group (Erastin 5 µM) and control group. After 48 hours of treatment, the cells were counted, and a t-test was used to compare the number of cells between the two groups. (B) HCC4011, H1993, H1650 cells were divided into treatment groups (RSL3 1 µM) and the control group. After 48 hours of treatment, the cells were counted, and a t-test was used to compare the number of cells between the two groups. CCK8 assay was used to detect the sensitivity of HCC4011, H1993, H1650 to afatinib (C), Erlotinib (D), RSL3 (E), Erastin (F). (G,H) HCC827, HCC827R, H1975, H1975R cells were divided into two groups: treated group (RSL3 1 µM or Erastin 5 µM) and control group. The cells were counted after treatment for 72 hours, 120 hours, and 168 hours, and the number of cells in each group was compared with the t-test. *, P<0.05; **, P<0.005; ***, P<0.0005; ****, P<0.00005. EGFR-TKI, epidermal growth factor receptor-tyrosine kinase inhibitor.