Figure 6.

Pin1 decreased but phosphorylated GluA1 Ser⁸³¹ and CaMKII Thr²⁸⁶ increased in the human brain tissues of patients with epilepsy. (A) Pin1 immunostaining decreased in the human epileptic brain sections. Scale bar, 50 μm. (B, C) Western blots also confirmed the decreased expression of Pin1 in the human brain tissues of patients with epilepsy (control, n = 6; epilepsy, n = 12; ^*P < 0.05). Although the total AMPA receptors did not change significantly, phosphorylated GluA1 Ser⁸³¹ and CaMKII Thr²⁸⁶ both increased in the human neocortex tissues and in Pin1 KO mice (control, n = 6; epilepsy, n = 12; ^**P < 0.01).