TABLE 3.

Estimated mean differences in cocaine-free days between topiramate and placebo among BIS-11 subscores

	Estimated mean difference (%)	Lower 95% C.I.	Upper 95% C.I.	p-value	Bonferroni corrected p-value
Second-order
Attentional
>Median	3.32	−6.24	12.87	0.495	0.990
≤Median	11.92	2.66	21.18	0.012	0.024
Motor
>Median	4.98	−4.76	14.72	0.316	0.632
≤Median	10.81	1.53	20.09	0.023	0.046
Nonplanning
>Median	7.82	−2.65	18.28	0.143	0.286
≤Median	8.04	−0.62	16.71	0.069	0.138
First-order
Attention
>Median	3.28	−7.16	13.70	0.536	0.999
≤Median	11.37	2.62	20.12	0.011	0.022
Cognitive
>Median	6.37	−5.52	18.27	0.293	0.586
Instability
≤Median	7.50	−0.50	15.49	0.066	0.132
Motor
>Median	6.45	−4.01	16.91	0.226	0.452
≤Median	8.23	−0.36	16.82	0.060	0.120
Perseverance
>Median	11.64	0.36	22.92	0.043	0.086
≤Median	5.42	−2.72	13.55	0.191	0.382
Self-control
>Median	13.64	3.22	24.05	0.010	0.020
≤Median	4.32	−4.18	12.82	0.318	0.636
Cognitive
>Median	5.98	−5.08	17.03	0.288	0.576
Complexity
≤Median	8.78	0.57	16.98	0.036	0.072

Bold values indicate statistical significance p < 0.05.