TABLE 1.

Selected drug-induced SJS/TEN and their association with HLA.

Drug category	Drug	Associated HLA locus	Odds ratio (OR)	Ethnicity	References
Antiseizure	Carbamazepine	HLA-B*15:02	2504	Taiwan Han Chinese	Chung et al. (2004)
			1357	Taiwan Han Chinese	Hung et al. (2006)
			25.5	Thai	Locharernkul et al. (2008)
			54.76	Thai	Tassaneeyakul et al. (2010)
			9.54	Thai	Sukasem et al. (2018a)
			71.4	Indian	Mehta et al. (2009)
			16.15	Malaysian	Chang et al. (2011)
			184	Central Chinese	Wu et al. (2010)
			114.826	Southern Han Chinese	Wang et al. (2011)
			152	Central and northern Han Chinese	Zhang et al. (2011)
			89.25	Hong Kong Han Chinese	Cheung et al. (2013)
			6.5	Indonesian	Yuliwulandari et al. (2017)
		HLA-A*31:01	25.93	European	McCormack et al. (2011)
			7.3	Korean	Kim et al. (2011)
			33.9	Japanese	Ozeki et al. (2011)
		HLA-B*15:11	18.0	Korean	Kim et al. (2011)
			9.76	Japanese	Kaniwa et al. (2010)
			54.12	Thai	Jaruthamsophon et al. (2017)
		HLA-B*15:21	40.73	Thai	Jaruthamsophon et al. (2017)
			7.53	Filipino	Capule et al. (2020)
		HLA-B*11:01	63.89	Spanish Caucasian	Ramirez et al. (2017)
	Phenytoin	HLA-B*15:02	5.1	Taiwan Han Chinese	Hung et al. (2010)
			3.50	Hong Kong Han Chinese	Cheung et al. (2013)
			18.5	Thai	Locharernkul et al. (2008)
			5.71	Malaysian	Chang et al. (2017)
		HLA-B*15:13	11.28	Malaysian	Chang et al. (2017)
		HLA-B*56:02	10.40	Thai	Tassaneeyakul et al. (2016)
		HLA-B*38:02	12.67	Thai	Manuyakorn et al. (2020)
		HLA-A*02:01/Cw*15:02	14.75	Spanish Caucasian	Ramirez et al. (2017)
		HLA-B*46:01	2.341	Thai	Sukasem et al. (2020b)
	Lamotrigine	HLA-B*15:02	5.1	Taiwan Han Chinese	Hung et al. (2010)
			4.89	Thai	Koomdee et al. (2017)
		HLA-B*15:02	3.59	Hong Kong Han Chinese	Cheung et al. (2013)
		HLA-A*31:01	11.43	Korean	Kim et al. (2017)
		HLA-A*02:07	7.83	Thai	Koomdee et al. (2017)
		HLA-B*38:01	147	Spanish Caucasian	Ramirez et al. (2017)
	Phenobarbital	HLA-A*01:01	11.66	Thai	Manuyakorn et al. (2016)
		HLA-B*13:01	4.60	Thai	Manuyakorn et al. (2016)
	Oxcarbazepine	HLA-B*15:02	80.7	Taiwan Han Chinese	Hung et al. (2010)
			27.90	Taiwan Han Chinese and Thai	Chen et al. (2017)
Antihyperuricemia	Allopurinol	HLA-B*58:01	580.3	Taiwan Han Chinese	Hung et al. (2005)
			40.83	Japanese	Kaniwa et al. (2008)
			97.8	Korean	Kang et al. (2011)
			80	89% of European Caucasian	Lonjou et al. (2008)
			348.3	Thai	Tassaneeyakul et al. (2009)
			229.7	Hong Kong Han Chinese	Chiu et al. (2012)
			203.40	Mainland Han Chinese	Cao et al. (2012)
			127.60	Mainland Han Chinese	Cheng et al. (2015a)
			579.0	Thai	Sukasem et al. (2016)
Decreasing intraocular pressure	Methazolamide	HLA-B*59:01	249.8	Korean	Kim et al. (2010)
			305	Mainland Han Chinese	Yang et al. (2016)
		HLA-Cw*01:02	22.1	Korean	Kim et al. (2010)
			12.1	Mainland Han Chinese	Yang et al. (2016)