Table 6. Investigations recommended in patients with confirmed AIS. Adapted from (7).

Investigation category	Tests
Haematological	Full blood count, iron status and haemoglobinopathy screen
Biochemical	Total plasma homocysteine, alpha galactosidase, fasting blood sugar, fasting cholesterol, and lipoprotein(a). Lupus anticoagulant and ACLA, and discuss beta 2GP1 testing with haematology if necessary
Cardiac	Electrocardiogram (ECG) and echocardiogram
Cerebrovascular	Arch to vertex-CTA or MRA. Transcranial Doppler in patients with SCD
Genetic	To be considered on a case by case assessment

AIS, arterial ischaemic stroke; ACLA, anticardiolipin antibody; CTA, CT angiogram; MRA, MR angiogram; SCD, sickle cell disease.