FIG. 1.

Frontonasal dysplasia phenotype. A–B: Facial features of the proband at 21 months of age, including high hairline, frontal bossing, hypertelorism, ptosis, and broad nasal tip. C–D: Facial features of the proband’s mother as an adult, including high frontal hairline, frontal bossing, hypertelorism, unilateral ptosis, broad nasal tip, and prognathia. E–H: Cranial CT 3D reconstruction for the proband at 31 months of age demonstrating wide anterior fontanelle (E, arrow), metopic synostosis (E, arrowhead), parietal foramina (F, arrowheads), sagittal synostosis (F, arrow), persistent craniopharyngeal canal (G and H, arrow), and premature lateral spheno-occipital synchondrosis (H, arrowheads). [Color figure can be seen in the online version of this article, available at http://wileyonlinelibrary.com/journal/ajmga]