Table 1.
Comparison of the clinical characteristics of patients with and without hepatocellular carcinoma
|
Characteristic
|
no-HCC group (n = 145)
|
HCC group (n = 121)
|
P
value
|
| Age ≥ 60 yr, n (%) | 41 (28.3) | 64 (52.9) | < 0.001 |
| Male, n (%) | 99 (68.3) | 91 (75.2) | 0.133 |
| Etiology of liver cirrhosis, n (%) | |||
| HBV | 101 (60.7) | 76 (62.8) | 0.363 |
| HBV + alcohol | 31 (21.4) | 45 (37.2) | 0.006 |
| HBV + HEV | 1 (0.6) | 0 (0.0) | - |
| HBV + schistosome | 1 (0.6) | 0 (0.0) | - |
| Smoking history, n (%) | 21 (14.5) | 51 (42.1) | < 0.001 |
| Family history of HBV-related HCC, n (%) | 10 (6.9) | 23 (19.0) | 0.004 |
| Medication history | |||
| Duration of NA treatment, yr, median (P25, P75) | 3.9 (2.1, 5.8) | 5.4 (2.3, 6.9) | 0.067 |
| LAM resistance, n (%) | 18 (12.4) | 27 (22.3) | 0.021 |
| HBsAg level, IU/L, median (P25, P75) | 255.0 (56.0, 678.0) | 269.0 (67.0, 656.0) | 0.456 |
| HBeAg positive, n (%) | 37 (25.5) | 21 (17.4) | 0.136 |
| HBV DNA negative, n (%) | 67 (46.2) | 39 (32.2) | 0.033 |
| ALB, U/L | 36.29 ± 7.98 | 33.34 ± 6.62 | 0.002 |
| ALT, U/L, median (P25, P75) | 27.00 (18.00, 37.00) | 32.00 (21.27, 62.00) | 0.006 |
| AST, U/L, median (P25, P75) | 33.00 (23.00, 47.00) | 44.50 (31.65, 96.85) | < 0.001 |
| GGT, U/L, median (P25, P75) | 33.00 (20.00, 46.00) | 61.50 (32.75, 160.75) | < 0.001 |
| ALP, U/L, median (P25, P75) | 99.00 (73.00, 126.00) | 134.50 (92.00, 198.85) | < 0.001 |
| TB, μmol/L, median (P25, P75) | 20.41 (13.81, 44.60) | 24.46 (16.60, 42.80) | 0.192 |
| FBS, mmol/L, median (P25, P75) | 5.17 ± 0.68 | 6.99 ± 1.31 | 0.025 |
| Ascites, n (%) | 33 (20.0) | 43 (34.7) | 0.022 |
| Child-Pugh class, n (%) | |||
| A | 81 (55.9) | 55 (45.5) | 0.001 |
| B | 38 (26.2) | 26 (21.5) | 0.561 |
| C | 26 (17.9) | 40 (33.1) | 0.002 |
| AFP ≥ 20 μg/L, n (%) | 14 (9.7) | 56 (46.3) | < 0.001 |
| PT s, median (P25, P75) | 13.25 (11.80, 14.20) | 13.51 (12.41, 15.02) | 0.475 |
AFP: Alpha-fetoprotein; ALB: Albumin; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; FBS: Fasting blood sugar; GGT: Glutamyl transpeptidase; HBeAb: Hepatitis B e-antibody; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; LAM: Lamivudine; PT: Prothrombin time; SD: Standard deviation; TB: Total bilirubin.