Figure 1.

Interaction between the mRNA methylation ‘writers,’ ‘erasers’ and ‘readers.’ In the nucleus, m⁶A methyltransferases (green semicircles) are named ‘writers’. Their binding proteins (blue semicircles) are named ‘readers,’ and the demethylases (pink semicircles) are named ‘erasers.’ The m⁶A ‘writers’ include METTL3/14/16 and WTAP, and the ‘erasers’ that can eliminate the m⁶A from mRNAs include FTO and ALKBH5. Furthermore, m⁶A is recognized by the ‘readers,’ such as YTHDF1/2/3, HNRNPA2/B1, and HNRNPC. YTHDF1/2/3 (yellow circles) promotes the translation of m⁶A-modified mRNAs in the cytosol. m⁶A, N⁶-methyladenosine; METTL, methyltransferase-like; WTAP, Wilms tumor 1-associating protein; FTO, Fat mass and obesity-associated protein; ALKBH5, alkB homolog 5; YTHDF, YTH domain protein families; HNRNP A2/B1, heterogeneous nuclear ribonucleoprotein A2/B1; HNRNPC, heterogeneous nuclear ribonucleoprotein C.