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. Author manuscript; available in PMC: 2021 May 10.
Published in final edited form as: Mol Cell Neurosci. 2018 Mar 24;89:33–41. doi: 10.1016/j.mcn.2018.03.010

Fig. 4.

Fig. 4.

TrkB.T1 enhances LTP in presymptomatic mSOD1 mice.

Representative fEPSP recordings from wt (A), mSOD (B) and mSOD1/T1−/− (C) animals. For each case, the traces are obtained before (gray) and 50 min (green) after the high-frequency stimulation (HFS) conditioning protocol (2 times at 100 ms, 100 Hz trains). The mSOD1 mice (n = 8 slices) exhibit enhanced levels - with respect to wt mice (n = 9 slices) - of long-term potentiation (LTP) 50 min following HFS; at the same time point, mSOD1/T1−/− mice (n = 8 slices) display levels of LTP resembling those of wt mice (D). Following HFS, the potentiation of fEPSP is higher in mSOD1 mice compared to wt mice; the post-HFS fEPSP is comparable between wt mice and mSOD1/T1−/− mice (E). Asterisks denote statistical significant differences (* = p < 0.05). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)