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. 2021 Apr 27;17:17448069211011315. doi: 10.1177/17448069211011315

Figure 1.

Figure 1.

The correlation effect between P2X3 and TRPV1 of SNI rats in vivo. (a) After TRPV1 is activated, the flinching times (2 min intervals) of SNI rats with P2X3 agoinst/P2X3 antagonist. (b) After TRPV1 is activated, the flinching times (10 min intervals) of SNI rats with P2X3 agoinst/P2X3 antagonist. (c) After TRPV1 is activated, the licking time (2 min intervals) of SNI rats with P2X3 agoinst/P2X3 antagonist. (d) After TRPV1 is activated, the licking time (10 min intervals) of SNI rats with P2X3 agoinst/P2X3 antagonist. Compared with SNI+vehicle+capsaicin group, △P<0.05, △△P<0.01, compared with SNI+α,β-meATP+capsaicin group, #P<0.05, ##P<0.01, (SNI+vehicle+capsaicin group: n=5, SNI+α,β-meATP+capsaicin group: n=5, SNI+TNP-ATP+capsaicin group: n=5). (e) After P2X3 was activated, the flinching times (2 min intervals) of SNI rats with TRPV1 agoinst/TRPV1 antagonist. (f) After P2X3 was activated, the flinching times (10 min intervals) of SNI rats with TRPV1 agoinst/TRPV1 antagonist. (g) After P2X3 was activated, the licking time (2 min intervals) of SNI rats with of SNI rats with TRPV1 agoinst/TRPV1 antagonist. (h) After P2X3 was activated, the licking time (10 min intervals) of SNI rats with of SNI rats with TRPV1 agoinst/TRPV1 antagonist. Compared with SNI+vehicle+α,β-meATP group, △P<0.05, △△P<0.01, compared with SNI+ capsaicin +α,β-meATP group, #P<0.05, ##P<0.01, (SNI+vehicle+α,β-meATP group: n=5, SNI+capsaicin+α,β-meATP group: n=5, SNI+capsazepine +α,β-meATP group: n=5)