Figure 1.

Immune response after immunization with rRBD from Sars-Cov-2 with aluminum hydroxide plus OMV from Neisseria meningitidis strains B:8:P1.6 (prep1) or C:2a.P1.5 (prep2). The IgG production in sera collected 15 and 45 days after the first immunization dose was measured by ELISA and can be observed in (a). The IgA production was accessed 15, 30, 37 and 45 days after the first immunization dose (b). Additionally, 45 days after the first immunization dose, the animals were euthanized and the splenocytes were cultured under rRBD stimuli. The IgG production in culture supernatant was evaluated by ELISA (c) and the number of cells/10⁶ splenocytes producing IFN-γ (d) or IL-17 (e) was evaluated through ELISpot