Table 1.
Association of Timeless expression with clinicopathological variables in patients with CRC (n = 114)
| Variable | Group | Number of cases (%) | Timeless expression | P value | |
|---|---|---|---|---|---|
| High | Low | ||||
| Gender | |||||
| male | 66 (57.9) | 33 | 33 | 1 | |
| female | 48 (42.1) | 24 | 24 | ||
| Age (years) | |||||
| ≥60 | 70 (61.4) | 41 | 29 | 0.021* | |
| <60 | 44 (38.6) | 16 | 28 | ||
| Tumor Diameter (cm) | |||||
| > 5 | 43 (37.7) | 19 | 24 | 0.334 | |
| ≤5 | 71 (62.3) | 38 | 33 | ||
| Tumor Location | |||||
| Colon | 76 (66.7) | 39 | 37 | 0.691 | |
| Rectum | 38 (33.3) | 18 | 20 | ||
| Clinical stage | |||||
| I-II | 55 (48.2) | 18 | 37 | 0.000*** | |
| III-IV | 59 (51.8) | 39 | 20 | ||
| T stage | |||||
| T1–2 | 20 (17.5) | 5 | 15 | 0.014* | |
| T3–4 | 94 (82.5) | 52 | 42 | ||
| N stage | |||||
| absent | 57 (50) | 17 | 40 | 0.000*** | |
| present | 57 (50) | 40 | 17 | ||
| M stage | |||||
| M0 | 100 (87.7) | 47 | 53 | 0.087 | |
| M1 | 14 (12.3) | 10 | 4 | ||
| Vascular invasion | |||||
| absent | 85 (74.6) | 36 | 49 | 0.005** | |
| present | 29 (25.4) | 21 | 8 | ||
| Perineural invasion | |||||
| absent | 71 (62.3) | 34 | 37 | 0.562 | |
| present | 43 (37.7) | 23 | 20 | ||
* P < 0.05, ** P < 0.001, *** P < 0.0001