Table 8.
Univariate Association of STK11 co-mutation vs. No co-mutation with Covariates in Patients with KRAS mutation from LCMC 2 (N=232).
| Variable |
STK11 mutation (N= 17) |
STK11 No mutation (N= 75) |
P |
|---|---|---|---|
| Age (Years) | |||
| Median (IQR) | 61 (58 - 71) | 67 (58 - 71) | 0.081 |
| Gender | |||
| Male | 9 (52.94) | 30 (40) | 0.330 |
| Female | 8 (47.06) | 45 (60) | |
| Race | |||
| Non-White | 1 (5.88) | 3 (4) | 0.322 |
| Unknown | 0 (0) | 10 (13.33) | |
| White | 16 (94.12) | 62 (82.67) | |
| Smoking history | |||
| Current Smoker | 2 (11.76) | 11 (14.86) | 1.000 |
| Former smoker | 14 (82.35) | 58 (78.38) | |
| Never smoker | 1 (5.88) | 5 (6.76) | |
| ECOG | |||
| 0 | 5 (29.41) | 12 (16) | 0.442 |
| 1 | 10 (58.82) | 51 (68) | |
| 2 | 2 (11.76) | 12 (16) | |
| Surgery history for lung cancer | |||
| Yes | 7 (41.18) | 30 (40) | 0.929 |
| No | 10 (58.82) | 45 (60) | |
| Radiation treatment history for lung cancer | |||
| Yes | 3 (17.65) | 26 (34.67) | 0.173 |
| No | 14 (82.35) | 49 (65.33) | |
| Chemotherapy history for lung cancer | |||
| Yes | 8 (47.06) | 40 (54.05) | 0.602 |
| No | 9 (52.94) | 34 (45.95) | |
| Targeted therapy given | |||
| Yes | 1 (6.67) | 3 (4.55) | 0.567 |
| No | 14 (93.33) | 63 (95.45) |
Data are presented as number of patients (column %) or median (IQR, interquartile range). P-value is calculated by Wilcoxon rank-sum test for age; and chi-square or Fisher’s exact test for categorical variables, where appropriate.